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What Does Bio-Identical Pellet Hormone Therapy for Men Involve?

If you are considering testosterone pellet therapy, the first step is scheduling a consultation. Prior to your appointment, we will need to review your lab work to ensure a comprehensive evaluation. If you already have recent blood test results – including PSA, testosterone levels, estrogen levels, and a complete blood count (CBC), along with fasting blood sugar and cholesterol levels – you should bring them with you. If not, we will provide a lab order so you can complete the necessary tests before your consultation.

During your appointment, we will discuss your medical history, current symptoms, and personal health concerns to determine whether testosterone pellet therapy is the right option for you. If you are deemed a good candidate, we will proceed with treatment following a thorough review of your baseline lab results.

The pellet insertion procedure is simple, quick, and virtually painless. A small area near the waistline, just below the “love handle” region, is numbed with a local anesthetic. Once the area is numb, a tiny incision – about three millimeters (1/16 of an inch) – is made. A specialized instrument then places the testosterone pellets into the deep fatty tissue, ensuring they remain secure and gradually release testosterone over time. The small opening is covered with a steri-strip, which should naturally fall off within four to five days as the skin heals.

Most men begin to notice improvements in exercise tolerance, mood, and energy levels within the first month of treatment. Significant changes in body composition (such as decreased body fat and increased muscle mass) typically take several months and multiple treatments. By the time you begin your second set of pellets, you should experience noticeable improvements in nearly all areas. These benefits tend to continue for a year or longer as your body reaches its optimal hormonal balance.

Maintaining a healthy diet, particularly one lower in carbohydrates, along with regular exercise, can further enhance the results. While the vast majority of men see substantial benefits, there are rare cases (approximately 1%) where a patient does not feel enough improvement after the second round of treatment to continue.

How Can Men Benefit from Bio-Identical Pellet Hormone Therapy?

Based on extensive research and clinical experience, the most effective approach to testosterone supplementation is one that provides a stable, consistent level of the hormone to support a man’s optimal health and performance. An excellent example is bio-identical pellet hormone therapy.

Traditional methods like gels often result in inconsistent absorption, while injections create fluctuations with spikes and drops in testosterone levels. Oral supplementation is not a viable option, as testosterone is metabolized by the liver before reaching the bloodstream.

On the other hand, bio-identical testosterone pellets offer a superior alternative by delivering a steady, sustained release of testosterone over approximately four months per insertion. This consistent delivery system ensures more stable hormone levels, avoiding the highs and lows associated with other methods. For men seeking long-term hormonal balance, testosterone pellet therapy is one of the most reliable and effective options available.

Does Bio-Identical Pellet Hormone Therapy for Men Cause Side Effects?

Testosterone pellet therapy generally provides significant benefits with minimal side effects. Muscle strength and size may modestly increase, particularly when combined with consistent weight training; however, testosterone pellets will not cause excessive or disproportionate muscle growth.

One notable effect is a reduction in sperm count, which typically occurs about a month after starting pellet therapy. However, this should not be relied upon as a form of birth control, as sperm counts naturally return to baseline approximately six months after the last pellet insertion.

In most men, red blood cell production increases with testosterone therapy. In a small percentage, hematocrit levels (a measure of red blood cell concentration) may rise slightly above the normal range. Scientific studies have not linked this to an increased risk of blood clots, likely due to testosterone’s ability to reduce inflammatory clotting factors. However, if elevated hematocrit is a concern, donating blood every few months can help maintain optimal levels.

There is no evidence that testosterone pellets contribute to male pattern baldness. While some men experience hair loss due to dihydrotestosterone (DHT), this is a different hormone from testosterone. Research has not shown that increasing testosterone levels leads to elevated DHT levels.

A common misconception is that testosterone therapy causes “steroid rage” or increases the risk of early death from cancer or heart disease. These assumptions stem from the abuse of synthetic “testosterone mimic” designer drugs by bodybuilders. Unlike bio-identical testosterone, these artificial compounds bind abnormally to hormone receptors, disrupting normal physiology and potentially causing long-term organ damage. To protect overall health, both men and women should avoid estrogen or testosterone-like substances that are not molecularly identical to human hormones. 

Extensive research has shown that even when healthy men receive significantly higher-than-normal doses of bio-identical testosterone, no harmful effects occur. Furthermore, all modern behavioral studies confirm that bio-identical testosterone supplementation does not lead to increased aggression.

To learn more or schedule an appointment with Dr. Richards, feel free to contact us today.

Medical References* 

1 Healio
2 National Library of Medicine
3 National Library of Medicine